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Ac for Targeted Alpha Therapy (TAT) using the experimental fast reactor JoyoMaeda, Shigetaka; Kitatsuji, Yoshihiro
Enerugi Rebyu, 42(10), p.19 - 22, 2022/09
Ac-225 is attracting attention as an alpha-emitting medical radioisotope. Since its demand is expected to increase, domestic production of Ac-225 is required from the viewpoint of Japan's medical research and economic security. To establish the technical bases for the Ac-225 production, JAEA has evaluated the radioactivity that can be produced in the experimental fast reactor Joyo and designed the concept that upgrades the existing facilities for transporting the irradiated target from Joyo to a neighboring PIE facility rapidly. Efficient Actinium-225 Separation from Ra-226 irradiated in a fast reactor was studied. Ba and La were used as alternatives to Ra and Ac, respectively. By using DGA resin as an adsorbent, it can be expected that Ra and impurities generated by irradiation will be removed and Ac will be isolated. This study has revealed that Joyo can sufficiently produce Ac-225 as a raw material for pharmaceuticals.
Ouchi, Kazuki; Kitatsuji, Yoshihiro; Maeda, Shigetaka; Takaki, Naoyuki*
no journal, ,
Efficient Actinium-225 Separation from Ra-226 irradiated in fast reactor was studied. Ba and La were used as alternatives to Ra and Ac, respectively. By using DGA resin as an adsorbent, it can be expected that Ra and impurities generated by irradiation will be removed and Ac will be isolated.
Sano, Aaru; Maeda, Shigetaka; Itagaki, Wataru; Sasaki, Shinji; Sasaki, Yuto*; Takaki, Naoyuki*
no journal, ,
Ac-225 is attracting attention as an alpha emitting medical radioisotope. Since its demand is expected to increase, domestic production of Ac-225 is required from the viewpoint of medical research and economic security of Japan. To establish the technical bases for the Ac-225 production, JAEA has evaluated the radioactivity can be produced in the experimental fast reactor Joyo and designed the concept that upgrades the existing facilities for transporting the irradiated target from Joyo to a neighboring PIE facility rapidly. This study has revealed that Joyo can sufficiently produce Ac-225 as a raw material for pharmaceuticals.
Sano, Aaru; Sasaki, Yuto*; Sasaki, Shinji; Iwamoto, Nobuyuki; Ouchi, Kazuki; Kitatsuji, Yoshihiro; Maeda, Shigetaka; Takaki, Naoyuki*
no journal, ,
Ac-225 can be applied to cancer treatment of various sites, but world supply is scarce. In this study, in order to study the production of Ac-225 using fast neutrons, we evaluated the amount of Ac-225 produced by fast neutron irradiation of Joyo. Burn up calculations were performed with Ra-226 as the target using ORIGEN2.2 for the evaluation of the production amount. In addition, the uncertainty of Ac-225 production was evaluated from the nuclear reaction cross section of the target nuclide and the neutron flux of Joyo. This study showed that a large amount of Ac-225 can be produced by irradiating Ra-226 at Joyo. In the future, we will improve the accuracy of evaluation of the production amount through demonstration experiments.
Takaki, Naoyuki*; Iwahashi, Daiki*; Sasaki, Yuto*; Maeda, Shigetaka
no journal, ,
The production technology of medical radioisotopes (RI) using existing nuclear fission reactors has been studied to improve/achieve their domestic preparedness in Japan. The target nuclides currently considered in our project are Mo/Tc which is the most commonly used ones in medical diagnosis and Ac-225 which is recently known as effective alpha emitting nuclide for targeted alpha-particle therapy. Existing fission reactors, PWRs and Joyo, have potentials to work as excellent facilities for medical isotope production, as by-products of heat/electricity generation without consuming electricity and need for new plant construction.
Ac production rate and its uncertainty in the experimental fast reactor Joyo utilizing the total Monte Carlo methodSasaki, Yuto; Iwahashi, Daiki*; Maeda, Shigetaka; Takaki, Naoyuki*
no journal, ,
Ac-225 is attracting attention as an alpha emitting medical radioisotope. Since its demand is expected to increase, domestic production of Ac-225 is required from the viewpoint of medical research and economic security of Japan. To establish the technical bases for the Ac-225 production, JAEA has evaluated the radioactivity can be produced in the experimental fast reactor Joyo and designed the concept that upgrades the existing facilities for transporting the irradiated target from Joyo to a neighboring PIE facility rapidly. This study has revealed that Joyo can sufficiently produce Ac-225 as a raw material for pharmaceuticals.